Kukar lab discovers granulins made in lysosome, revealing potential therapeutic targets for neurodegenerative diseases
- Progranulin Pathways: Model of intracellular processing of progranulin into stable, lysosomal granulins. [Holler et al., 2017 eNeuro; CC BY 4.0]
Christopher Holler, PhDLysosome Link: Using new tools, Emory scientists can see granulins in lysosomes. Granulin deficiency is important in neurodegenerative diseases, but their function has been unclear. Red shows where granulins are in cells, and green is LAMP1, a marker of lysosomes.
The Kukar Lab published a paper titled, "Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRNMutations," in eNeuro.