Stephen Traynelis, PhD
Office: 5025 Rollins Research Center
Additional Contact Information
Emory University School of Medicine
Department of Pharmacology
1510 Clifton Road, Rollins Research Center Room 5025
Atlanta, Georgia 30322-3090
- PhD, University of North Carolina, 1988
- Postdoctoral Fellow, University College, London England, 1989-1991
- Postdoctoral Fellow, The Salk Institute, 1992-1994
Mechanism of activation and modulation of glutamate receptors, regulation of excitatory synaptic transmission, and neuroinflammation
Current Research Activities: My research activities are centered on expanding our understanding of the structure-function relationship of glutamate receptors, with particular emphasis on the therapeutic implications of regulation of these receptors by extracellular ions and second messenger systems. Our experiments are directly relevant to neuronal damage in stroke, the mechanisms of seizure generation, and the molecular basis for learning and memory. We use electrophysiological recordings of whole cell currents and single ion channels to elucidate the biophysical basis of receptor regulation.
Current Research Interests: We are currently working towards an understanding of how blood derived serine proteases can influence glutamate receptor function under conditions of blood-brain-barrier breakdown. In addition, we study the regulation of NMDA receptors by protons and Zn; pH inhibition of NMDA receptor function is particularly relevant for stroke since ischemia is accompanied by an acidification of the extracellular environment. We also are working on the basis for gating of AMPA-type glutamate receptors, with an emphasis on regulation by PKA and CAMKII-linked second messenger systems. Additional experiments probe the connection between the permeation of ions and the time course of channel gating.
- View publications on PubMed