Edward Morgan, PhD

Professor

Emory University School of Medicine

Office: 5119 Rollins Research Center

Phone: 404-727-5986; Lab Number: 404-727-0364

Fax: 404-727-0365

Email: etmorga@emory.edu

Additional Contact Information

Mailing Address:

Emory University School of Medicine

Department of Pharmacology
1510 Clifton Road, Rollins Research Center Room 5119

Atlanta, Georgia 30322-3090

Additional Websites

Education

  • PhD, University of Glasgow, 1979
  • Postdoctoral Fellow, University of Michigan, 1979-1982
  • Visiting Scientist, Karolinska Institute, Stockholm, Sweden, 1982-1986
  • Emory University, 1986
  • APPOINTMENTS:, Assistant Professor, Emory University School of Medicine, 1986-1992, Associate Professor, Emory University School of Medicine, 1992-1999, Professor, Emory University School of Medicine, 1999

Biography

Research Area:
Regulation of drug metabolizing enzymes; cytochrome P-450; inflammation; biological effects of nitric oxide
Research Interests:
Our laboratory aims to advance fundamental understanding of the regulation of cytochrome P450 enzymes, in order to provide the basis for rational design of drug doses and regimens in disease states and to identify P450 enzymes as novel therapeutic targets in infectious or inflammatory disease. We use live and sterile models of infection to study the differential regulation of hepatic cytochrome P450s in response to inflammation. Current research is focused on the down-regulation and induction of expression of the central enzymes of drug metabolism, the cytochromes P450 in a rodent model of enteropathogenic e.coli infection and a model of inflammatory bowel disease. We also study both the transcriptional and posttranscriptional mechanisms of regulation of P450 by inflammatory responses, with a current focus on the understudied area of regulated P450 protein degradation. In particular, we are elucidating the mechanisms by which endogenous nitric oxide in hepatocytes targets particular P450 enzymes for regulated degradation.


     



Publications