Thota Ganesh, PhD

Assistant Professor

Emory University School of Medicine

Office: 5019 Rollins Research Center

Phone: 404-727-7393; Lab Number: 404-727-5635

Fax: 404-727-0365

Email: tganesh@emory.edu

Additional Contact Information

Mailing Address:

Emory University School of Medicine

Department of Pharmacology
1510 Clifton Road, Rollins Research Center Room 5019

Atlanta, Georgia 30322-3090

Education

  • PhD, Osmania University, Hyderabad, India, 1999
  • Postdoctoral Fellow, Indian Institute of Technology (IIT), Bombay, India, 1999-2000
  • Postdoctoral Fellow, University of Durham, England, 2000-2001

Biography

Research Area:
Drug Discovery, Epilepsy, Alzheimer's Disease and ALS
Research Interests:
Inflammation is a key component in a variety of CNS diseases including status epilepticus, epilepsy, amyotrophic lateral sclerosis and Alzheimer’s disease; peripheral diseases such as arthritis and cancer. The overarching goal of my research is to find a clinically useful EP2 modulator to use as an anti-inflammatory and neuroprotective agent on patients with chronic inflammatory disease, where EP2 activation plays a deleterious role (Ganesh J. Med. Chem. 2014). I am open to collaborate and work with new investigators within and outside of Emory University, with an overall goal of deriving a medicinal chemistry solution with a small molecule to a biological problem.

I have acquired medicinal chemistry knowledge from the laboratories of Prof. Dr. David Kingston at Virginia Tech, and Dr. Dennis Liotta at Emory Institute for Drug Development (Ganesh et al., PNAS 2004, Ganesh et al., J. Med. Chem. 2007, Ganesh, T. Bioorg. Med. Chem. 2007). I worked on a variety of medicinal chemistry projects driven by structure activity relationships (SAR), ligand based drug design (LBDD) and structure based drug design (SBDD) strategies for hit-to-lead synthesis.

Publications