Rita Nahta, PhD

Assistant Professor

Emory University School of Medicine

Office: C4008 Winship Cancer Institute

Phone: 404-778-3097; Lab Number: 404-778-3064

Fax: 404-727-0365

Email: rnahta@emory.edu

Additional Contact Information

Mailing Address:

Emory University School of Medicine

Department of Pharmacology, Winship Cancer Institute, Room C4008
1365-C Clifton Road

Atlanta, Georgia 30322-3090

Education

  • PhD, Duke University, 2000
  • Postdoctoral Fellow, Harvard Medical School, 2000-2002
  • Postdoctoral Fellow, M.D. Anderson Cancer Center, 2002-2004

Biography

Research Area:
Biological and therapeutic implications of growth factor signaling crosstalk in breast cancer
Research Interests:
Our laboratory focuses on the biological and therapeutic implications of growth factor signaling crosstalk in breast cancer. Significant advances in the treatment of metastatic breast cancer include the development of therapies targeted against specific cancer-causing molecules. However, the success of these mono-targeted therapies is often limited by cross-talk between multiple signaling pathways. One molecule that is overexpressed in about 25% of metastatic breast cancers is the HER2/erbB2 oncogene. Approved treatments for HER2-overexpressing breast cancer include the HER2-targeted antibody trastuzumab and the dual EGFR/HER2 kinase inhibitor lapatinib. While both drugs successfully treat a percentage of HER2-overexpressing metastatic breast cancers, a significant number of patients show primary or acquired resistance to these treatments. My laboratory is interested in understanding how cross-talk between HER2 and other growth factor signaling pathways affects the biology of HER2-overexpressing breast cancers, including how signaling cross-talk promotes resistance to trastuzumab and lapatinib. By understanding the basic signaling mechanisms contributing to therapeutic resistance, we can identify new molecular targets against which future drugs can be developed.
    

Publications